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Allergy, Asthma Immunol., vol

Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids

However, its best to avoid it during pregnancy and breastfeeding, as its effects on newborns havent been studied enough

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