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The low immunogenicity of AAV allows for repeated dosing, while its ability to transduce both dividing and non-dividing cells makes it a suitable vector for siRNA delivery to post-mitotic tissues such as neurons and muscle cells

Because injectable NAD+ becomes bioavailable more rapidly, it may more quickly engage in cellular processes such as mitochondrial energy production, DNA repair and oxidative stress regulation

CNTF has been demonstrated to prevent cell degeneration following axotomy and promote neurite growth and neuronal survival (170)

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Not every patient is an appropriate candidate, and treatment recommendations are always individualized