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Once polyamines reach the epidermal/apoplastic space, the same PUT-type transporters and long-distance transport processes operate, so differences between spray, drench or priming are largely quantitative (dose, area exposed, timing) rather than mechanistically distinct

Pediatr Pulmonol 2001

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The break trial represents valuable experiment for any GHK-Cu user completing 6+ month treatment course - discontinuing for 2-3 months reveals how well benefits persist, helps determine whether cycling or continuous use better suits individual biology, provides psychological break from rigid routine, and offers cost savings period while assessing necessity of ongoing application

This indirectly corroborates the pivotal role of OS in receptor regulation [Citation91]