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Molecules, 26 (10), 121

Conclusion Indeed, the effects of CLA supplementation on inflammation and oxidative stress remain controversial, and conclusive evidence regarding its ability to directly mitigate excess oxidative stress and inflammation is lacking

In addition, another study reported that both mechanical hyperalgesia and thermal hyperalgesia due to oxaliplatin can be reduced by the use of a higher dose of melatonin (20 mg/kg, i.p.) in rats [48]

The results revealed that compared to OVA control, the AGE + OVA group displayed a significantly higher frequency of CD4 + tetramer-positive cells, which provides compelling evidence that AGEs exposure amplifies OVA-specific Th2 responses (Supplementary Fig