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Distinguishing direct pharmacological anti-inflammatory actions from secondary metabolic improvements requires further mechanistic studies and randomized controlled trials specifically designed to assess inflammatory outcomes as primary endpoints

Conducted experimental studies Study 1 Material Male rabbits subjected to appropriate preoperative nutrition

Observations indicate stimulation of osteogenic processes, including increased osteoblast engagement and improved mineralized matrix formation, contributing to enhanced bone continuity and strength during regeneration

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The bound protein was eluted using 20 mM HEPES pH 7.4, 100 mM NaCl, 2 mM MgCl 2 , 0.01% (w/v) LMNG and 0.0006% (w/v) CHS, 1 M peptide, and 5 mM EGTA and 0.1 mg/mL Flag peptide