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Wu L, Bao F, Li L, Yin X, Hua Z

Large reviews and clinical statements note that B12 injections do not consistently improve energy, mood, or weight loss in non-deficient individuals

Those who have had bariatric surgery or other gastrointestinal procedures often have less stomach surface area available for vitamin absorption

In the STEP-1 trial of 1,961 adults (Wilding and colleagues, Once-Weekly Semaglutide in Adults with Overweight or Obesity, New England Journal of Medicine, 2021), participants on semaglutide 2.4 mg lost an average of 14.9 percent of their body weight at 68 weeks, compared to 2.4 percent on placebo