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28 When compared against a contemporary education and exercise (EDX) approach in the LEAP randomised clinical trial, EDX was significantly more successful than CSI in both the short and long term, as measured with a global rating of change score

Houmard JA

10.1073/pnas.71.10.3879 Proc

Reduced and alkylated peptides were then desalted and concentrated using Chromabond C18WP spin columns (730522, Macherey-Nagel) according to manufacturer protocols

Unfortunately, the specific mechanisms of MSC-based treatment have rarely been investigated among the studies, except that platelet-rich plasma improves the therapeutic efficacy of MSCs (127)