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FIGURE 5 Age- and sex-dependent effects of pomegranate extract on TMAO response Although the overall effect of the pomegranate extract on plasma TMAO AUC was null ( P = 0.945), we observed that the participants with increasing TMAO were older (Figure 6A), and in particular the three oldest women ( n = 3

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This dysregulation is partially mediated by alterations in the NKCC1/KCC2 expression ratio, which governs intracellular chloride gradients and GABAergic polarity (see Section 'Disruption of Neurotransmitter Balance by Anesthetics'), as well as through direct interference with the functional integrity of GABA A Rs and NMDA receptors (Cabrera et al