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1 Introduction Hypertensive disorders of pregnancy (HDP), encompassing gestational hypertension (GH), preeclampsia and eclampsia (PE), represent a major global health burden, persistently ranking among the top causes of maternal and perinatal morbidity and mortality ( Among the array of hypertensive disease biomarkers, serum uric acid (UA) has garnered increasing attention ( This study aims to investigate the relation between maternal serum UA measured during early and mid-pregnancy (before 24 th weeks gestation) and the subsequent developed HDP, specifically based on Chinese pregnant women