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Erastin, one of the earliest discovered ferroptosis inducers, inhibits system Xc - (SLC7A11/SLC3A2), thereby impairing GSH synthesis, leading to ROS accumulation and inducing GBM cell death ( 2+ levels, increased GSH levels, and suppressed expressions of ferroptosis-related proteins such as GPX4, NRF2, and SLC7A11 ( RAS-selective lethal 3 (RSL3) is a known ferroptosis inducer

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In addition, batch growth data from literature 48 was used to evaluate model predictions, quantitatively

Liposomal-based: As discussed, this is the gold standard for glutathione absorption

The results of this study may contribute to our understanding of the complex interaction between exercise, nutrition and mitochondrial health and pave the way for future research in this area