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Paracetamol is also useful in the management of more severe pain, where it allows lower dosages of additional non-steroidal anti-inflammatory drugs (NSAIDs) or opioid analgesics to be used, thereby minimizing overall side-effects

Data access statement: We collected detailed information on BPH between 1990 and 2021 from the GBD ( The GBD 2021 database contains statistical data of 354 diseases in 204 countries and territories from 1990 to 2021

While antioxidant response enzymes are well-characterized transcriptional targets of NRF2, it is recently becoming clear that NRF2 also supports cellular detoxification through metabolic rewiring to support the antioxidant systems