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Claudin-4 is a barrier-forming tight junction protein in the intestinal epithelium that strengthens transepithelial resistance by limiting paracellular ion flux and inhibiting the channel activity of pore-forming claudins to fine-tune barrier function

10.3390/nu14183670 Nutrients 34 CiprianiR.VillaP.CheceG.LauroC.PaladiniA.MicottiE.et al (2011)

Additionally, oxidative stress affects early embryo development and implantation which impacts fertility

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jamanetwork.com Evidence suggests that sperm quality in males over the past 50-70 years has declined, likely due to a combination of dietary and lifestyle factors and exposure to endocrine-disrupting chemicals