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The PS-TREM2 signaling pathway is crucial for synaptic refinement in brain regions such as the hippocampus and dorsal lateral geniculate nucleus, where pruning is essential for proper circuit maturation (158, 179)

A systematic review and meta-analysis of vitamin D and calcium in preventing osteoporotic fractures

Selenium Rich Foods and Vitamin C Serve as Glutathione Cofactors Selenium, an essential trace mineral abundantly present in foods such as sardines, liver, and sunflower seeds, is crucial for the enzymatic processes that support the activity of glutathione and glutathione related enzymes

The investigators followed the patients for 51 months

This ROS vicious cycle (Figure 2), present in different tissues and cells, causes exponentially accelerating oxidative stress with age (Pinto and Moraes, 2015)