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doi: 10.1016/j.celrep.2016.09.008 22 MacIverNJMichalekRDRathmellJC

Studies have indicated that 47% of cirrhosis patients endure sleep disturbances, while 69% experience both disturbed sleep and depression

For example, the 5-year survival rate for the most common clear cell RCC after metastasis is 30 genes have been reported to be abnormally hypermethylated in prostate cancer, including genes involved in hormonal response, cell cycle regulation, cell invasion and DNA damage repair

As a result, the excess free radicals begin to damage the bodys cells and tissues

By a variety of mechanisms, NO can react with different molecules, under ambient oxygen, and the derived products can damage the cellular macromolecules, such as lipids, DNA bases, proteins as well as thiols