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Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops

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More importantly, subsequent studies led to the trap of a sulfenic acid intermediate in EgtE-catalysis

The abnormalities of NQO1 enzyme activity have been linked to the pathophysiological mechanisms of multiple neurological disorders, including Parkinson's disease, Alzheimer's disease, epilepsy, multiple sclerosis, cerebrovascular disease, traumatic brain injury, and brain malignancy

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