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Description

Upon reaction with HO , these radicals form 3-hydroxylysine, a neurotransmitter analogue 3,4 dihydroxyphenylalanine (DOPA) and, in interaction with another tyrosyl radical, forms a fluorescent protein crosslink dityrosine

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The cysteinereactive seleniumbased compound Ebselen likewise facilitates SOD1 maturation by assisting the formation of the stabilizing intramolecular SOD1 disulfide bond, significantly reducing mutant SOD1 aggregation in vitro and in vivo in mutant SOD1 mice

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