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F., Blazer, D

The liver is the primary site of P450 enzyme activity, and there are over 50 different P450 enzymes with unique substrate specificity

The study revealed that, in the presence of mutant HTT, a significant portion of genes with altered expression exhibited pronounced changes in DNA methylation, particularly in regions with low CpG content known to undergo methylation changes due to neuronal activity

Thus, the oxidative damage mediated by OTA may be divided into the direct (covalent DNA adduction) and indirect (oxidative DNA damage) mechanisms [83]

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