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First, in non-malignant tissues, PDK isoforms play essential physiological roles, particularly in highly energy-demanding organs such as the heart and skeletal muscle, where they regulate substrate utilization by limiting carbohydrate oxidation and promoting metabolic flexibility [190, 191]

found that fosinopril (FOS), a TLR4 inhibitor, can inhibit NF-B signaling in both in vivo and in vitro models

Pyrosequencing: history, biochemistry and future