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After nicotine is absorbed into the bloodstream through smoking or other means, it undergoes metabolism primarily in the liver, where it is converted into cotinine

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More recently, the activity of controlled release nicotine from dry powder inhaler formulations was assessed via the locomotor activity of C57BL/6 mice

There had been a trend for manufacturing cigarettes with lower nicotine yield in recent decades but at the same time there is a reported tendency for the smokers of such low-nicotine yield cigarettes to smoke more intensely and to inhale the smoke more deeply than the smoker of plain cigarettes [15]

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