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Wenger and colleagues showed that THC alters pituitary LH release by inhibiting the release of LHRH, injecting THC into the third cerebral ventricle of male rats [92]

Although RYO smokers are less likely than cigarette smokers to make a quit attempt, they are not less likely to succeed in quitting, 17,18,45,46 and therefore further work on how to promote cessation efforts among this population, whether via inserts or any other means, is warranted

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