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48 The aqueous extract of the stem and leaves of Jamun was active against S

A number of studies have also validated the therapeutic potential of sommarutide in NASH [113,120,121]

Dose and route heterogeneity: animal studies use very variable doses (from 10 nanograms to 10 micrograms per kg) and different routes (intraperitoneal, subcutaneous, intravenous, oral), which complicates comparisons between protocols and establishing a clear dose-response relationship

Additionally, studies have revealed that icariin and associated improvements in behavioral tests are accompanied by anti-inflammatory action, anti-oxidant action, Inhibited activation of NF-kB signaling, as well as a decrease in levels of SGK1 (serum and glucocorticoid-regulated kinase 1) and FKBP5 (FK506 binding protein 5) expression (Wei et al., 2016)