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Despite studies investigating the antifibrotic potential of TGF/Smad inhibition, we believe that the early induction of TGF-mediated fibrosis by fibroblast injection intervention in the acute and subacute stages of IDD will benefit patients by stabilizing and maintaining disc height to minimize the loss of biomechanical functions of the intervertebral disc

To mitigate thermal effects and prevent tissue damage, the Food and Drug Administration (FDA) mandates that the mechanical index ratio, defined as the peak negative pressure divided by the center frequency, should be less than 1.9 [361]

ROS directly cause lung damage as a result of DNA, lipid, carbohydrate, and protein alterations, and activate local inflammatory responses that contribute to COPD development and progression (7983)

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Castejn, M