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Metabolomics may provide a holistic approach in identifying pivotal metabolites with authentic diagnostic significance ( The present study showed that the metabolism of about 11 amino acids, including (1) metabolites related to GSH biosynthesis, (2) methionine, (3) glycine, serine, and threonine, and (4) phenylalanine, had been changed in plasma of patients with thyroid nodules compared to healthy subjects

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Thirty rats were randomly distributed into five groups of six animals each

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