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Though non-specific, certain pathogenic factors including genetic predisposition, visceral hypersensitivity, food intolerance, altered gut-brain axis and gut dysmotility, dysfunction of innate immunity and dysbiosis may contribute to this disorder (Figure 1)

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Future well-designed, prospective studies with larger sample sizes and comprehensive baseline assessments are essential to validate these results, minimize potential biases, and establish the efficacy, safety, and optimal dosing of L-carnitine supplementation in this population

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