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The action of estradiol is primarily directed by interaction with the estrogen receptor (ER) nuclear receptors (alpha and beta) in peripheral target tissues further modulated via feedback by GH and IGF-1 (Veldhuis et al., 2006)

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The anti-diabetic efficacy of diverse polyphenols has been demonstrated in both in vivo and in vitro studies, supporting their potential as therapeutic agents (388, 389)