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Delivery of peptide and protein drugs over the bloodbrain barrier

Specifically, the indirect mechanism is chelation of transition metals, which prevents participation within the Haber-Weiss (Kehrer, 2000) or Fenton reaction, while the direct mechanism involves donating or receiving of electrons, scavenging radicals, and consequently preventing their reaction with biological molecules

Western blotting studies demonstrated higher expression of CBS (but not CSE or 3-MST) in the tumor tissue, as compared to the surrounding nominally normal tissue which was also removed during surgery [6]

[DOI] [PubMed] [Google Scholar] 140.Song M, Liu T, Shi C, Zhang X, Chen X

Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA