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Mice on high-fat diets exhibited significantly reduced glucose levels after six weeks of supplementation with CGA-rich green coffee extract (100 mg/kg body weight) [119]

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In vitro and in vivo studies further revealed that CGA inhibits Notch1 and Stat3 signaling, reducing lipid accumulation and renal fibrosis, downregulating SREBP1c, and upregulating CPT1A, thereby enhancing fatty acid oxidation [159]