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The team enrolled 60 women aged 60 to 75 years who met Asian Working Group criteria for sarcopenia and randomly assigned them to two groups

Caffara M, Serracca L, Gustinelli A, Vencia W, Rossini I, Prearo M, Fioravanti ML

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Metformin may also increase liver accumulation of B12, meaning it is less available, and it may alter reabsorption of bile acids, disrupting the enterohepatic circulation of B12