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Brownlee RD, Kass PH, Sammak RL

Various potential toxic molecules are included in blood which have the ability to elevate the output of various free radicals such as reactive oxygen species (ROS) causing oxidative stress [16, 48]

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A common redox marker does not make glutathione a universal therapy

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition