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No standardised human research protocol exists

The change may be beneficial, harmful, or even fatal, but mutations are rare occasions

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In specific to EMBASE, the search term was modified as (metabolomics/exp OR metabolomics OR metabonomics/exp OR metabonomics OR metabolome/exp OR metabolome OR metabolites/exp OR metabolites OR metabolic profiling/exp OR metabolic profiling) AND (myopia/exp OR myopia OR short sightedness/exp OR short sightedness OR myopic degeneration OR macular degeneration/exp OR macular degeneration OR age-related maculopathy OR age-related macular degeneration/exp OR age-related macular degeneration OR glaucoma/exp OR glaucoma OR ocular hypertension/exp OR ocular hypertension OR glaucomatous optic neuropathy/exp OR glaucomatous optic neuropathy OR diabetic retinopathy/exp OR diabetic retinopathy OR diabetic eye disease/exp OR diabetic eye disease OR diabetic macular edema/exp OR diabetic macular edema OR diabetic eye complications/exp OR diabetic eye complications OR ocular disorders OR eye diseases/exp OR eye diseases)