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Thus, Htt reduces Cu 2+ to Cu 1+ , and copper promotes its aggregation, mediated by histidine residues ( Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt

Certain mutations cause ATP7B to accumulate in the endoplasmic reticulum, impairing its proper localization to the Golgi apparatus or cell membrane, preventing copper from being excreted in bile and leading to its buildup in the liver, brain, and other tissues (29)

Zinc: Oral route

The NM signal area was considerably smaller in patients with PD for 25 years compared to those with early PD (Fabbri et al., 2017)

Chromatographic separation is performed on an Agilent series 1100 HPLC device with a Zorbax Eclipse XDB-C18 column and fluorometric detector