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In p53-mutant colon cancer cells, MDM4 (murine double minute 4) inhibits ubiquitinated degradation of GPx4 by upregulating the expression of the E3 ubiquitin ligase TRIM21, a regulatory mechanism that allows GPx4 to maintain high protein levels in p53-mutant colon cancer cells, which, in turn, inhibits the occurrence of ferroptosis

Elemental mercury can be released from dental amalgam restorations [180] and can then be converted into inorganic mercury in the body which can accumulate in the brain [181]

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