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While TH is clearly beneficial in preventing death, it does not provide complete neuroprotection 4

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Second, excess intracellular iron is sequestered by cytosolic ferritin, and can be dynamically released upon iron depletion via ferritinophagy 139,140

Horm Res 65(suppl 4):180 Guevara-Aguirre J, Vasconez O, Martinez V, Martinez AL, Rosenbloom AL, Diamond FB Jr, Gargosky SE, Nonoshita L, Rosenfeld RG (1995) A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency

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