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Interferon beta is a cytokine with several functions, which include downregulation of antigen presentation, thereby suppressing T cell activity, induction of IL10, which skews the differentiation of CD4+ T cells toward a Th2 phenotype, blockade of T cell migration by decreasing adhesion molecules and matrix metalloproteinase 9 ( The PRISMS-15 study evaluated long-term outcomes of 290 patients enrolled in the original PRISMS study 15 years after initial randomization, 145 of whom had data on conversion to SPMS

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