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Clinical studies have shown that coagulation activation during ECMO initially leads to the deposition of fibrin, platelets, and leukocytes on the circuit surface (63), which can develop into sarcoid thrombosis in some patients (64)

The calcineurin-TFEB-p62 pathway mediates the activation of cardiac macroautophagy by proteasomal malfunction

Frequency : Initially, treatments are usually scheduled 2-3 times a week, with a reduction to once a week for maintenance after 6-8 weeks

Neurofibromatosis: the effect of pregnancy on the skin manifestations

However, animal reproduction studies are not always predictive of human response