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Intramuscular injection should be used only when this route of administration is necessary, and repeated injections at the same site should be avoided

Additional Documentation Requirements - Signed informed consent detailing risks, benefits, and expected outcomes.- Treatment log including prescribed concentration and patient response.- Post-treatment care instructions provided and documented

Cryptography may also be needed to protect audit records stored on computer systems from disclosure or modification

The striking loss of acini upon ablation of SOX2 + cells further confirmed that these are the sole progenitors for the acinar lineage in the SLG and is consistent with a recent report demonstrating pancreas acinar cells are not equipotent but contain a subset of progenitors (Wollny et al , 2016)

Running them together is expected to make these effects more frequent and more intense during the co-escalation phase (roughly weeks 9-20 in the staggered protocol)