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Proteomes 11 (4), 34

Double Trouble-Buffer Selection and His-Tag Presence May Be Responsible for Nonreproducibility of Biomedical Experiments

When a tissue is damaged, AST and ALT enzymes leak out of the cells into the blood primarily from mitochondria or the cytoplasm

As such, the circulating and metastatic cancer cells upregulate the PGC-1 to facilitate oxygen consumption rate oxidative phosphorylation, and mitochondrial biogenesis to uphold metastasis (137)