"We ask that the public await theoutcome of the investigation
10.1186/s13287-023-03476-4 157 YuW.LvY.XuanR.HanP.XuH.MaX
CPRIT Fellowship, 2013
DEX induced ferroptosis by upregulating CD82-P53-mediated downregulation of SLC7A11 and GPX4
Data from observational studies indicates that individuals with BD tend to have lower blood levels of the omega-3 fatty acids EPA and DHA, essential to neuronal function, and higher ratios of omega-6 to omega-3 fatty acids, which have been linked with higher levels of inflammatory markers.13,16 Additionally, some studies have found that individuals with BD had lower levels of many essential micronutrients, including iron, zinc, manganese, selenium, folate, vitamin B12, and vitamin D.16 Lower levels of the antioxidant vitamins A, E, and C have been associated with higher oxidative stress levels in individuals with BD.16 Research on how calcium intake and blood calcium levels affect BD is limited and has led to mixed findings, with evidence of both low and elevated blood calcium levels in participants with BD.2,13-16 Vida Velasco-Popov, MS, RD, CDN, dietitian at New York-Presbyterian Hospital and first author on a recent study on nutrition and BD, highlights these nutrition challenges: Common dietary patterns observed in this population are high in calories, saturated fat, and sugar, which not only increase the risk for aforementioned comorbidities, but also increase risk for certain micronutrient deficiencies, including vitamin D, folate, vitamin B12, and vitamin B6 to name a few. She recommends screening clients with BD for common deficiencies like folate and B12, particularly those who are taking valproic acid
