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In contrast, E-cadherin mRNA expression was highly attenuated in Igf1r fl/fl mice upon experimental pulmonary metastasis, while this reduction was milder in CreERT2 mice (Fig

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The most common initial symptom in this large series, observed in 68% of the patients when first seen, was the insidious onset of proximal leg stiffness followed by rigidity concurrently in the abdominal, lumbosacral and thoracic paraspinal muscles, lumbar hyperlordosis and impaired gait

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