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As vascular risk factors contribute to cognitive impairment (CI) and dementia, we explored whether cardiovascular disease (CVD) risk moderates the relationship between blood-based dementia biomarkers and CI

It has one genuine pharmacological advantage (reduced IGFBP binding extending free-peptide availability) that is real at the molecular level but unproven to translate into superior clinical outcomes in humans

doi: 10.1371/journal.pone.0181122

Additional information Peer review information Nature Communications thanks Keith Blackwell and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Immediately thereafter, cardiac perfusion was performed with 20 mL of ice-cold phosphate-buffered saline (PBS) to remove residual blood