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Description

The principal function attributed to ICP34.5 involves enhancing viral propagation across peripheral tissues alongside central nervous systems, contributing significantly toward HSV, and inducing neurovirulence via various mechanisms including protein phosphatase I (PPI) dephosphorylating eIF2, thus preventing shutoff from host protein synthesis while enabling continuous production (11, 30, 31)

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however, we noted that we would continue to consider how to implement condition-specific measures such as this measure under MIPS (86 FR 65692 through 65694)

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