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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

22, G/D-CuP group exhibited a significantly reduced proportion of CD86-positive cells compared to the NC group

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Masuda, M., Sawa, M

Therapy-induced senescent cells can re-enter the cell cycle to show aggressive proliferative and cancer stem-like properties, presenting a risk for recurrence and treatment resistance