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Moreover, the tumor microenvironment (TME) in HCC is enriched with M2-polarized tumor-associated macrophages (TAMs), a dominant immunosuppressive population that promotes NK cell dysfunction and exhaustion [5, 11, 12]

Small molecules directly targeting the clock proteins offer the potential to directly manipulate endogenous circadian rhythm to improve clock-regulated output processes, as well as to treat diseases associated with clock misalignment (for a comprehensive review on the topic see 135

AE rates were high with approximately half of patients reporting at least one AE

doi: 10.1128/MCB.01204-10

Y., Nikolic-Paterson, D