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GH-Axis : Due to age-related decline in pituitary function, older adults may require a longer cycle duration (16-24 weeks) and may need to use the standard or advanced doses of GHSs to achieve a therapeutic effect

Mechanistically, high ferritin light chain (FTL) in TAMs promotes M2 polarization through facilitating ferroptosis by inhibiting the expression of iPLA2, which expedites tumor progression through inducing an immunosuppressive microenvironment, promoting tolerance to anti-PD-L1 therapy, as well as facilitating glioma angiogenesis[177]