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The most distinct feature of classical IBs is their extra functions to positively regulate NF-B ( When cells are stimulated by cytokines or pathogen-associated molecular patterns (PAMPs) binding to membrane receptors, signaling cascades initiate and finally converge on the activation of the IB kinase (IKK) complex (Table 1)

Cacho-Valadez B, Munoz-Lobato F, Pedrajas JR, Cabello J, Fierro-Gonzalez JC, Navas P, et al

This dynamic interplay not only enhances the survival adaptability of tumors but also increases their metabolic plasticity