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These findings suggest that modulating endogenous H 2 S production or administering H 2 S donors like NaHS could offer a novel therapeutic strategy for PAH by upregulation of the COX-2/PGI2 axis (Li et al., 2014)

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The cells were plated on VTN-coated plates and cultured in the neuronal induction medium (NIM): Dulbeccos Modified Eagles Medium (DMEM)/F12 (21,331,020, Thermo Fisher Scientific), HEPES (15 mM), N2 supplement (Thermo Fisher Scientific), GlutaMAX (2 mM, Thermo Fisher Scientific), MEM Non-Essential Amino Acids (0.1 mM

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Group A subjects were exposed to a 90 dB HL 3 kHz pure tone for 10 min