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From the clinical point of view this is, in addition to the weight change, explicit evidence for adherence to the dietary intervention

Thus the inability of the heart to regenerate cardiac muscle, coupled with a predominant fibrotic injury response remain major fundamental obstacles to treating heart disease

doi: 10.1016/j.ijsu.2016.02.084

Moreover, oral bioavailable formulations of curcumin were safe for human at the dose of 500 mg two times in a day for 30 days, but there are still few trials and more studies are needed specially on nanoformulations and it should be discussed in a separate article

Studies on intestinal cholesterol absorption in the human