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Moreover, concentrations of circulating endotoxin and the number of bacteria in the intestinal lymph nodes and the lymphatic circulation also correlate with disease severity [80]

In the latest EULAR and ACR guidelines for RA management, bDMARD tapering is considered a feasible practice in patients with sustained remission [21, 141]

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10.3389/FNAGI.2022.998292/PDF [DOI] [PMC free article] [PubMed] [Google Scholar] Yin J, Jin X, Shan Z et al (2017) Relationship of sleep duration with all-cause mortality and cardiovascular events: a systematic review and dose-response meta-analysis of prospective cohort studies