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Deeper lines show improvement

It was also observed that the drug solubilization was more effective for the most hydrophobic drugs (Danthron and Griseofulvin) than for more hydrophilic ones (Phenacetin)

67 Similar outcomes were observed by Singh et al., 44 who performed a cross-sectional study on 13 regular kratom consumers to nail down the effects of chronic kratom administration (more than 20 years)