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172 Pretreatment with the KD is associated with a reduction of pro-inflammatory cytokines, such as IL-1 and tumor necrosis factor alpha (TNF-), which are induced by lipopolysaccharide injection, thereby suggesting that KD has anti-inflammatory properties

Changes in biomarkers after exposure to oxidative inducers are typically used to assess a natural products antioxidant efficacy

However, the direct oxidation of Cys and, to a lesser extent, methionine residues with H 2 O 2 can give rise to reversible modifications, such as sulfenic acid or disulfides or as methionine sulfoxides, respectively, which can be reduced by cellular activities

System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo